Start here
2 bottles120 capsules · 120 days
$158total
$79 a bottle
- Lasts
- 120 days at 1 capsule a day
- Per day
- about $1.32
+ $9.99 shipping
- 120 days at 1 capsule a day
- Checkout adds $9.99 shipping
- 60-day money-back guarantee
Official website · Official U.S. Melonex shop
Melonex Official Website: Advanced Support Heart Capsules with L-Citrulline Malate and L-Arginine in One 500 mg Blend
Quick answer
Melonex is a dietary supplement for heart and circulation support, sold as capsules in a 60-count bottle. The label says to take one capsule a day with 8 oz of water, and allows up to two. Each capsule holds one 500 mg proprietary blend of L-citrulline DL-malate and two forms of L-arginine. It is not a blood-pressure medicine.
- The one label line, typed out
- The three amino acids, one by one
- Medicine and heart-attack flags
- Prices and the 60-day guarantee
- Secure checkout on the sales site
- 60-day money-back guarantee
- Ships from the U.S.
Written by the Melonex label desk · Updated
- 60 capsules a bottle
- 1 capsule a day
- 500 mg blend per capsule
Melonex capsules: white bottle, 60 servings. Brand render.
Three starred lines on the front of the label
As printed on the bottleHeart Support*
Arginine and citrulline have been studied for blood pressure at several grams a day; each Melonex capsule holds a 500 mg blend. (Shiraseb 2022, arginine and BP) (Luo 2025, citrulline/watermelon and BP)
Circulation Support*
The body's own nitric oxide helps keep vessels open. Pooled results for citrulline and blood pressure are mixed. (Cleveland Clinic, Endothelial Dysfunction) (Mirenayat 2018, citrulline and BP)
Natural Formula*
'Natural' has no set meaning for supplements, and it is not the same as safe. The three ingredients are amino acids bound to salts. (NIH ODS, Supplements: What You Need to Know) (Cleveland Clinic, Amino Acids)
| Form | Capsules, white bottle |
|---|---|
| Size | 60 capsules, 60 servings |
| Per capsule | One 500 mg blend, 3 names |
| Directions | 1 capsule a day with 8 oz water |
| Distributor | Instituto Experience, Lakeland, FL |
| Price | From $49 a bottle |
| Guarantee | 60 days, money back |
- 60 capsper bottle: 60 daily servings
- 500 mgone proprietary blend per capsule
- 3named amino acid forms in the blend
- 60 daysmoney-back window from purchase
One capsule: a single 500 mg blend
500 mgone Proprietary Blend per capsule, holding all three amino acids
Proprietary Blend 500 mg- L-Citrulline DL-Malate167 to 500 mg
- L-Arginine alpha-ketoglutarateup to 250 mg
- L-Arginine HClup to 167 mg
Each bar shows the range the label order allows for that ingredient (21 CFR 101.36, Supplement Facts), since the label lists them from most to least.
Label vs studies
L-Citrulline DL-Malate: most one capsule can hold500 mg
L-Citrulline DL-Malate: amount in a study3,000 mg
L-Arginine alpha-ketoglutarate: most one capsule can hold250 mg
L-Arginine alpha-ketoglutarate: amount in a study4,000 mg
These bars show the most each ingredient could weigh by label order, not measured amounts.
- 1 capsule a day, 60-capsule bottle
- The one label line typed out
- 45 public sources cited
- 60-day money-back guarantee
- No invented reviews or ratings
What it is01
What is Melonex?
Melonex is a dietary supplement sold as capsules in a white 60-count bottle with an ivory and oxblood label. The label sets one serving at one capsule, so one bottle is 60 servings.
The Supplement Facts panel has one line: Proprietary Blend, 500 mg. Inside it the label names L-Citrulline DL-Malate, L-Arginine (Alpha-Ketoglutarate dihydrate) and L-Arginine HCL. It does not say how much of each is in the capsule.
The front of the bottle reads "Melonex" and "Advanced Support", with three starred lines: Heart Support, Circulation Support and Natural Formula. The sales page describes "targeted nutritional support for heart health, healthy blood pressure, and overall cardiovascular wellness" and cites no studies (Melonex sales page). This site does not repeat those lines as findings, and each one is checked below.
Melonex is not a medicine and is not FDA-approved. The FDA does not approve dietary supplements before they are sold (FDA, Q&A on Dietary Supplements), and a structure-style claim may not say a product treats or prevents disease (FDA, Structure/Function Claims).
01
Capsules, not drops
The label we read is a capsule: hydroxypropyl methylcellulose shell, microcrystalline cellulose, magnesium stearate. See the capsule form page.
02
One blend, three names
500 mg in all. The label order caps what each name can be; the real split is not printed. See the 500 mg blend.
03
Sold by the brand
Order buttons here lead to the brand's own sales site, where the prices and the 60-day guarantee apply (Melonex sales page).
Claims vs evidence02
Does Melonex really lower blood pressure?
No one has published a study of Melonex itself, so nobody can say it changes blood pressure. The studies on its three names used grams a day, and the whole Melonex blend is 500 mg.
A pooled analysis of L-arginine given alone found small average drops, about 6 over 3 mm Hg, at grams a day (Shiraseb 2022, arginine and BP). Citrulline results are mixed: one analysis found a systolic drop of about 4 mm Hg and another found no effect (Barkhidarian 2019, citrulline and BP) (Mirenayat 2018, citrulline and BP). Mayo Clinic says arginine might help, and MSK calls the evidence mixed and limited (Mayo Clinic, L-arginine) (MSK, Arginine).
NCCIH says no dietary supplement has been shown to have effects comparable to the drugs used to treat hypertension (NCCIH, Hypertension). Blood pressure has no symptoms, so only a measured reading tells you where you stand (CDC, About High Blood Pressure).
- Label front“Heart Support*” and “Circulation Support*”Structure/function-style wording. The star leads to the FDA statement: not evaluated by the FDA, not intended to treat any disease. No source linked here tests this blend. (FDA, Structure/Function Claims)
- Sales page“targeted nutritional support for heart health, healthy blood pressure, and overall cardiovascular wellness”No study is cited on the page, and we found no trial of Melonex. NCCIH says no dietary supplement has been shown to have effects comparable to blood-pressure drugs. (Melonex sales page) (NCCIH, Hypertension)
- Ingredient listNot printed on the checkout pageThe label lists one 500 mg Proprietary Blend and three names, with no amount for any of them. Blend members must be listed from most to least by weight, so the order caps the amounts. (21 CFR 101.36, Supplement Facts)
- Label front“Natural Formula*”'Natural' does not always mean safe, and supplements need no FDA approval before sale. The three names are amino acids joined to salts. (NIH ODS, Supplements: What You Need to Know)
- Common claim“L-arginine helps blood pressure”Pooled trials of arginine alone show small average drops (about 6/3 mm Hg) at grams a day. Mayo says it might help; MSK calls the evidence mixed and limited. (Shiraseb 2022, arginine and BP) (Mayo Clinic, L-arginine) (MSK, Arginine)
- Common claim“Citrulline helps blood pressure”Mixed: one pooled analysis found a systolic drop of about 4 mm Hg and no clear diastolic change; another found no effect. Doses were 3 to 8 g a day. (Barkhidarian 2019, citrulline and BP) (Mirenayat 2018, citrulline and BP) (Cleveland Clinic, L-citrulline)
- Common question“Can it replace my blood-pressure medicine?”No. AHA says never cut back or quit on your own, and that no pills, vitamins or drinks replace prescription medicines and lifestyle changes. (AHA, Managing BP Medications)
Claims as printed on the sales site (Melonex sales page) and the label. Health claims need competent and reliable scientific evidence, generally human trials of the same product (FTC, Health Products Compliance Guidance).
Keep your care plan
Never cut back or quit a prescribed medicine because you started a supplement (AHA, Managing BP Medications). Chest pain, trouble breathing, fainting or sudden weakness means 911, not a capsule. The full review is on does Melonex work.
The 500 mg blend03
What is in the Melonex proprietary blend?
One line, 500 mg, three names. The amounts of the three are not printed, but the order they are listed in limits them.
Federal rules say the members of a blend must be listed from most to least by weight, and that the blend's number is the combined weight of all of them (21 CFR 101.36, Supplement Facts). So the first name, L-Citrulline DL-Malate, is at least a third of the blend, 167 mg or more. The second, L-Arginine alpha-ketoglutarate, can be at most 250 mg. The third, L-Arginine HCl, can be at most 167 mg.
500 mgone Proprietary Blend per capsule, amounts of the three names not printed
Proprietary Blend 500 mg- L-Citrulline DL-Malate167 to 500 mg
- L-Arginine alpha-ketoglutarateup to 250 mg
- L-Arginine HClup to 167 mg
Bars show the widest range the label order allows for each name (21 CFR 101.36, Supplement Facts). The real split is not printed.
These are ceilings from arithmetic, not measured amounts. The names are also salt forms: the malate, the alpha-ketoglutarate and the hydrochloride add weight, so the arginine and citrulline themselves weigh less than the amounts above.
Ingredient profiles
-
167to 500 mglabel order, of 500 mg01
L-Citrulline DL-Malate
#1 in the blend list: 167 mg or more
Amino acid citrulline joined to malic acid (a salt)
Evidence: Small average systolic drops in pooled trials, no effect in one analysis; small, low-certainty exercise benefitPer capsulenot printed; the label order puts it at 167 mg or more of the 500 mg blend
Studied at3 to 8 g (3,000 to 8,000 mg) a day of citrulline for 1 to 16 weeks
Watch forPossible bloating, cramping, diarrhea, sweating (Cleveland Clinic). That page lists no drug interactions; ask your pharmacist anyway.
Full profile -
up to 250mglabel order, of 500 mg02
L-Arginine AKG
#2 in the blend list: 250 mg at most
Amino acid arginine joined to alpha-ketoglutarate (a salt)
Evidence: Little human evidence; one review says clinical evidence is lackingPer capsulenot printed; the label order caps it at 250 mg of the 500 mg blend
Studied at4 g per dose, 12 g a day, in one sports trial of 35 men
Watch forNo authoritative safety page for alpha-ketoglutarate was found. Arginine cautions apply: blood-pressure medicines, nitrates, recent heart attack.
Full profile -
up to 167mglabel order, of 500 mg03
L-Arginine HCl
#3 in the blend list: 167 mg at most
Amino acid arginine as its hydrochloride salt
Evidence: Small average drops in pooled trials of arginine alone; Mayo says it might help, MSK calls the evidence mixed and limitedPer capsulenot printed; the label order caps it at 167 mg of the 500 mg blend
Studied atPooled trials of L-arginine alone mostly used grams a day; no further change above 9 g a day
Watch forNot recommended after a recent heart attack (Mayo, MSK, Cleveland Clinic). Can add to blood-pressure medicines; Mayo also names nitrates, sildenafil and potassium-sparing diuretics.
Full profile
Amounts vs research04
Is 500 mg enough to matter?
Compared with the amounts used in studies, the whole blend is small. We cannot say what the capsule delivers, because the amounts are hidden.
The citrulline summary Cleveland Clinic gives covers 3 to 8 g a day for 1 to 16 weeks (Cleveland Clinic, L-citrulline). The one arginine alpha-ketoglutarate trial we found gave 4 g per dose, 12 g a day, to 35 men in a sports study (Campbell 2006, L-arginine AKG trial). The whole Melonex blend, at one capsule, is 0.5 g. At the label's limit of two capsules it is 1 g.
Label vs studies
L-Citrulline DL-Malate: most one capsule can hold500 mg
L-Citrulline DL-Malate: amount in a study3,000 mg
L-Arginine alpha-ketoglutarate: most one capsule can hold250 mg
L-Arginine alpha-ketoglutarate: amount in a study4,000 mg
That is arithmetic, not a verdict. A studied dose says what was tested, not what works for you, and no study tested Melonex.
Know your numbers05
What do blood pressure numbers mean?
A cuff or clinic reading is the real score. High blood pressure is readings consistently at or above 130/80, and it usually has no symptoms (CDC, About High Blood Pressure).
The bands below follow the CDC, NHLBI and AHA (NHLBI, What Is High Blood Pressure) (AHA, Understanding Blood Pressure Readings). Type a reading to see where it falls. The gauge does not measure anything and does not diagnose; only a doctor or other medical professional can confirm high blood pressure.
Type a reading to see where it falls.
- NormalBelow 120 and below 80
- Elevated120 to 129 and below 80
- Stage 1130 to 139 or 80 to 89
- Stage 2140 or higher or 90 or higher
- Crisis rangeAbove 180 and/or above 120: call your clinician; with chest pain or trouble speaking, call 911
Bands from the CDC, NHLBI and AHA (CDC, About High Blood Pressure) (NHLBI, What Is High Blood Pressure) (AHA, Understanding Blood Pressure Readings). One reading is not a diagnosis: only a doctor or other medical professional can confirm high blood pressure, and no tool on the gauge measures your pressure. Use a validated upper-arm cuff (AHA, Home Blood Pressure Monitoring).
More on blood pressure basics and home monitoring.
How you take it06
How do you take Melonex capsules?
Take a single capsule each day with an 8 oz glass of water. The label also says you may take up to two a day.
The label prints it this way: "As a dietary supplement, take one (1) capsule daily with an 8 oz. glass of water. May take up to two (2) capsules daily." The sales page printed no serving size when we read it, so the label is the guide.
Starting at one capsule is the label's own first line. Do not take more than the label says, and ask your doctor before going to two if you take any blood-pressure medicine.
- 01
Check the seal and your list
On a new bottle, check that the safety seal is intact. Read the Supplement Facts. Note any blood-pressure medicine you take.
- 02
Pour an 8 oz glass of water
The label says to take one capsule with an 8 oz glass of water. That is a full cup, not a sip.
- 03
Take one capsule
One capsule a day is the label's starting line. The label also says you may take up to two a day; ask your doctor before going above one.
- 04
Keep your blood-pressure checks
A bottle lasts 60 days at one capsule a day. Keep your cuff or clinic readings going, and share what you take with your doctor.
More on the how to use page.
The label07
What does the Melonex label say?
The label says to take one capsule a day, prints one 500 mg blend with three names, and warns pregnant or nursing mothers, children under 18 and anyone with a known medical condition to ask a physician first.
It names the distributor, Instituto Experience of Lakeland, Florida. The manufacturer is not named, though the label says the product was made in an FDA registered facility. The bottle says it is made in the USA with globally sourced ingredients.
The numbered spots below explain each part in plain words. On a phone, the label scrolls sideways.
Tap a number to see that part of the label.
- Suggested use
One capsule daily, taken with an 8 oz glass of water. The label adds: 'May take up to two (2) capsules daily.'
- Storage
Keep away from heat, light and humidity to preserve freshness.
- Caution
Do not exceed the dose. Pregnant or nursing mothers, children under 18 and anyone with a medical condition: ask a physician first.
- Seal and children
Keep out of the reach of children. Do not use if the safety seal is damaged or missing. Store in a cool, dry place.
- Made in the USA
'Made in the USA with globally sourced ingredients.' No countries are listed.
- Distributor
Instituto Experience, Lakeland FL 33804, +1 (507) 448-8190, [email protected]. The maker is not named.
- Wordmark
Melonex, with 'Advanced Support' under it.
- Three starred claims
Heart Support*, Circulation Support*, Natural Formula*. The star leads to the FDA statement.
- Size
'60 capsules' and 'Dietary Supplement'.
- Serving
Serving size is 1 capsule, with 60 servings per container.
- One blend, 500 mg
Proprietary Blend 500 mg, listing L-Citrulline DL-Malate, L-Arginine (Alpha-Ketoglutarate dihydrate) and L-Arginine HCL. No amount is printed for any of the three. No daily value is set.
- Other ingredients
Hydroxypropyl methylcellulose (capsule), microcrystalline cellulose, magnesium stearate. No allergen line is printed.
- FDA statement
Not evaluated by the FDA; not intended to diagnose, treat, cure or prevent any disease.
- FDA registered facility
'This product has been manufactured in an FDA registered facility.' The facility is not named.
Every word is also typed out on the Melonex supplement facts page.
Safety check08
Is Melonex safe to take with your medicines?
It depends on you. Arginine can add to blood-pressure medicines, and three major health sites advise against it after a recent heart attack. Answer five quick questions, then talk to your doctor or pharmacist.
A checklist, not medical advice. See side effects and interactions and supplements and blood-pressure medicines.
What has evidence09
What actually moves blood pressure?
Salt, weight, eating pattern and activity have the numbers behind them. A supplement does not replace any of them or your medicine.
- SodiumAmericans eat over 3,100 mg a day on average; AHA says no more than 2,300 mg, ideally 1,500. Limiting it to 1,500 mg may lower pressure about 5 to 6 mm Hg. (AHA, How Much Sodium Per Day) (Mayo Clinic, 10 Ways to Lower BP)
- WeightAbout 1 mm Hg lower for each kilogram (2.2 pounds) lost, per Mayo Clinic's estimate. (Mayo Clinic, 10 Ways to Lower BP)
- Eating patternA DASH-style plan with less salt can work about as well as medicine for some people; Mayo estimates up to 11 mm Hg from a healthy diet. (NHLBI, DASH Eating Plan) (NHLBI, High Blood Pressure Treatment) (Mayo Clinic, 10 Ways to Lower BP)
- ActivityRegular aerobic exercise lowers systolic pressure about 5 to 8 mm Hg. Adults are advised 2.5 hours of moderate activity a week. (Mayo Clinic, 10 Ways to Lower BP) (AHA, Life's Essential 8)
- Tobacco and sleepQuitting tobacco and getting 7 to 9 hours of sleep are two of Life's Essential 8. (AHA, Life's Essential 8)
- Not knowingAbout 1 in 3 U.S. adults with high blood pressure are unaware and untreated. It has no symptoms, so only measuring shows it. (NHLBI, What Is High Blood Pressure) (CDC, About High Blood Pressure)
Read more on heart-healthy habits and the heart attack and stroke signs.
Pricing10
How much does Melonex cost?
Melonex sells in three packs: 2 bottles for $158, 3 bottles for $207 and 6 bottles for $294. That is $79, $69 or $49 a bottle.
The 2-bottle pack adds $9.99 shipping on the buy page. Three and six bottles are listed with free US shipping. Confirm the final total at checkout (Melonex sales page).
180-day supply
3 bottles180 capsules · 180 days
$207total
$69 a bottle
- Lasts
- 180 days at 1 capsule a day
- Per day
- about $1.15
Free US shipping
- 180 days at 1 capsule a day
- Free US shipping
- 60-day money-back guarantee
Lowest per bottle
6 bottles360 capsules · 360 days
$294total
$49 a bottle
- Lasts
- 360 days at 1 capsule a day
- Per day
- about $0.82
Free US shipping
- 360 days at 1 capsule a day
- Free US shipping
- 60-day money-back guarantee
Prices on the Melonex buy page, October 19, 2026 (Melonex sales page). The 2-bottle pack adds $9.99 shipping; the 3- and 6-bottle packs are listed with free US shipping. Per-day figures use 60 capsules a bottle at 1 capsule a day; the label also allows up to 2 capsules a day, which halves the days. We never show the struck "was" prices; the checkout shows the final total.
- Day 0
Order and keep the email
The desk will ask for the order ID in that email. The 60 days count from the date of purchase.
- Days 1-30
Use it as the label says
The brief says sales asks for at least 30 days of continuous use before a claim. Confirm the live policy on the checkout page. Keep your prescribed medicine going.
- By day 60
Ask for your money back
Call +1 (855) 889-3137 with your order ID before day 60, or write to the support address shown on mymelonex.com.
- Then
Mail with tracking
Post the bottles to the returns address and include your full name, email and order ID. Return postage is on you.
Details on the pricing page and the guarantee page.
Customer reviews11
What do Melonex customers say?
Review text on this site is filled in only from verified customer reviews. Until then the cards below are labelled slots, not real reviews.
4.5out of 5
Based on 694 verified ratings
Filled in only from reviews matched to a real order. How we check reviews.
Night cook here. I take blood-pressure tablets. Showed this bottle. They said keep the tablets. I keep it on the washer. I take it before I start the truck.
Pack review 1, as supplied · Photo supplied by the vendor
Warehouse floor, 4 a.m. start. Two-pack had $9.99 shipping. I bought six. That's the only math I trust. I keep it by the router. I take it when I clip the leash.
Pack review 2, as supplied · Photo supplied by the vendor
I drive a school bus. Heart copy on the page. I don't treat it like a stent. Walk still happens. I keep it on the piano. I take it when I sit in the bleachers.
Pack review 3, as supplied · Photo supplied by the vendor
See all on the reviews page.
Questions12
Melonex FAQ
What is Melonex?
Melonex is a dietary supplement in capsule form, 60 capsules to a bottle. Each capsule lists one 500 mg proprietary blend of L-citrulline DL-malate, L-arginine alpha-ketoglutarate and L-arginine HCl.
How do I take Melonex?
The label says one capsule a day with an 8 oz glass of water, and that you may take up to two capsules a day. Ask your doctor first if you take blood-pressure medicine.
Does Melonex lower blood pressure?
No source we found tests Melonex. Studies of arginine and citrulline alone show small or mixed changes at grams a day, and the whole blend is 500 mg.
Can I take Melonex instead of my blood-pressure medicine?
No. Never cut back or quit a prescribed medicine on your own. No supplement has been shown to work like blood-pressure drugs.
How much does Melonex cost?
2 bottles are $158 plus $9.99 shipping, 3 bottles $207 and 6 bottles $294 on the buy page. Confirm the total at checkout.
Is there a money-back guarantee?
The brief describes a 60-day money-back guarantee, with at least 30 days of continuous use asked. Call +1 (855) 889-3137 with your order ID and confirm the live policy.
Melonex: from $49 a bottle60 capsules · 2, 3 or 6 bottles · free US shipping on 3 and 6 · 60-day money-back guarantee
See packs